7th European Congress of Biogerontology

Программа конференции

Lecture by Anna Krementsova

^*MEDVEDEV D.A., ^** Krementsova A.V., ^***Moskalev A.A., ^†Kaurov B.A.,

Mamaev V.B., ††Artyuhov I.V., ^†††Pasyukova E.G.

Human Aging System Diagram

For today gerontology and interdisciplinary sciences have accumulated vast knowledges about ageing processes, there are hundreds hypotheses about the nature and mechanisms of aging. Therefore now presence of the synthesising project bridging knowledge together - natural continuation of development of a science about ageing At the same time the scientific thought in all areas uses visual languages for the decision of challenges more and more, as text representation of the information already limits scientific search. The purpose of project is creation of the general diagram of ageing of the person, including all mechanisms of ageing conventional to the present moment, beginning from molecular level and to level of an organism. Scientific principles of composition of the Human Aging System Diagram

1. The diagram describes process of aging of the human person. Aging processes, characteristic for other species are not included. At the same time in the diagram the data received on laboratory animals if necessary is used and extrapolated on the human person.

2. The diagram describes ageing processes, starts (above) with original causes (the natural processes - underlying processes of ageing), through disturbances of normal functioning of an organism, decline of various functional parametres and ends with pathologies and death of an organism (below).

3. The ageing diagram is a process diagram, i.å., its base elements are various limited in time and bound to ageing processes, going in an organism, bridged among themselves by relationships of cause and effect.

4. The diagram should give necessary detailed elaboration of processes of ageing. Detailed elaboration degree is defined by logic of processes and the demand of display of ageing at high enough level.

5. The diagram qualitatively describes, but does not model the ageing processes. In particular, the scheme is not equivalent to a computer model. Entering of numerical values into the diagram is supposed at later stages of development of the project.

6. The diagram is not the diagram of metabolic pathways.

As a result of work we created several diagrams connected to each other: the top level diagram, the basic detailed diagram and the diagram with the imposed interventions. On the top level diagram the main ways of ageing of the person are well visible. On the basic detailed diagram we have tried to reflect modern knowledge of concrete mechanisms of ageing. On the last diagram, on already known mechanisms of ageing we have superimposed ways of interventions to this process existing for today. The analysis carried out allows to tap new perspective points of the making of efforts in anti-aging struggle, and also to estimate possible by-effects of such influences.

Anna Krementsova is near our poster

^*International Research Centre for Advanced Technologies, Moscow, Russia

^** Emanuel Institute of Biochemical Physics, Academy of Sciences, Moscow, Russia

^***Komi Biology Institute, Syktyvkar, Komi Republic, Russia

^†Rossiysky Gerontological Scientific Clinical Center of Medical, Moscow, Russia

^††Institute of Biology of Aging, Moscow, Russia

^†††Institute of Molecular Genetics, Academy of Sciences, Moscow, Russia